P-363 Ovarian endometriosis deteriorates embryo development in ART cycles: An embryonic time-lapse study

Abstract Study question Does ovarian endometriosis deteriorate embryo quality in terms of morphokinetic parameters determined by time-lapse images? Summary answer Embryos from patients accelerate their early developmental events but decelerate after t5. Completion late were significantly delayed group. What is known already Endometriosis may affect the oocyte and consequently morphology implantation ability. Morphokinetic evaluation embryos provided more details might be utilised as a tool to distinguish Only scarce studies with limited case numbers have evaluated association between developments observation. Hardly any consensus has ever been drawn. design, size, duration The compared or without endometriosis. A total 52 cases 208 controls endometriosis, receiving assisted reproductive techniques April 2020 through June 2022, included for analysis. Propensity Score Matching age, BMI AMH was performed ratio 1:4 order eliminate confounding factors. Participants/materials, setting, methods We analyzed 737 top obtained 348 retrieval cycles at Taipei Fertility Center. 127 women affected 617 unaffected controls. All cultured incubator chamber completed blastulation. Main results role chance data showed that development distorted timing events, including tPNf (22.7 +/- 2.9 hr vs 23.5 4.1 hr, p = 0.03) t2 (25.2 3.1 26.1 4.4 shortened However, tM (89.7 9.8 86.6 11.4 0.006) tB (111.0 11.0 108.3 12.5 prolonged t5 observation found equal both group control (50.4 8.7 50.4 8.4 0.99). average KID score lower than normal control, it did not reached statistical significance (4.07 2.11 4.49 2.70, 0.27). initial serum hCG levels pregnant non-endometriosis participants higher (628.8 967.7 mIU/ml 1581.5 1885.1 mIU/ml, 0.01). Limitations, reasons caution This retrospective observational study propensity matching method factors such AMH. Wider implications findings effects on need further clarify; however, they serve markers selecting potential. Trial registration number Not applicable